The byes are here, the injuries never stop, and there’s another early-morning game in London. Whether you’re 5-0 or 0-5, this doesn’t figure to be an easy week for fantasy football owners, so don’t feel bad if you need some start ’em, sit ’em help. We’ve all been there. Fortunately, SN’s Vinnie Iyer is here to help with Week 6 fantasy lineup advice and NFL DFS picks.
As we said, the first round of byes takes out the Saints, 49ers, Falcons, and Jets. All things considered, fantasy owners aren’t getting hit too hard at most positions, especially wide receiver. Things will get tougher going forward, so it’s really injuries to guys like Saquon Barkley, Clyde Edwards-Helaire, and Russell Wilson that will cause the most issues. Game-time decisions like Dalvin Cook, Christian McCaffrey, Julio Jones, Chris Carson, and Sterling Shepard won’t help either, and neither will a 9:30 a.m. ET kickoff between the Jaguars and Dolphins. Have as much as you can in order on Saturday night, then check @SN_Fantasy on Twitter for all the latest injury and weather updates on Sunday morning.
Fantasy Football Week 6 Start ‘Em: Quarterbacks
- Josh Allen, Bills (at TEN)
- Patrick Mahomes, Chiefs (vs. WAS)
- Kyler Murray, Cardinals (vs. CLE)
- Tom Brady, Buccaneers (at PHI)
- Jalen Hurts, Eagles (vs. TB)
- Justin Herbert, Chargers (at BAL)
- Lamar Jackson, Ravens (vs. LAC)
- Dak Prescott, Cowboys (at NE)
- Matthew Stafford, Rams (at NYG)
- Aaron Rodgers, Packers (at CHI)
Joe Burrow, Bengals (at DET). Burrow should be OK after his neck injury scare and ready to roll into Motor City with more solid all-around passing numbers.
Trevor Lawrence, Jaguars (vs. MIA in London). He should put together a decent day In London via short-to-intermediate passing and doing some rushing of his own against a struggling overall defense.
Teddy Bridgewater, Broncos (vs. LV). The Raiders’ defense is showing its true colors, and he’s back in the 250-yard-and-two-TD conversation coming off his concussion return.
Jared Goff, Lions (vs. CIN). Goff should go back to throwing multiple TDs at home, as the Bengals have enough secondary holes for him to exploit in garbage time even with his limited receivers.
Baker Mayfield, Browns (vs. ARI). Baker busted out of his slump a little against the Chargers and will be pumped to play well opposite Kyler Murray with high volume stemming off the running game.
Taylor Heinicke, Washington (vs. KC, $5,800 on DraftKings, $7,300 on FanDuel). Heinicke can be messy at times, but this is a much better matchup at home than last week. He should produce purely based on garbage-time volume with plenty of help from his running backs to get some cheap tournament consideration.
Carson Wentz, Colts (vs. HOU, $5,400 on DraftKings, $6,700 on FanDuel). Wentz is starting to look good and comfortable in Frank Reich’s offense again, and his receivers also are helping out all over the field. The Texans at home will keep him in the 250-yard-and-two-TD range for strong return on investment in cash games.
Mac Jones, Patriots (vs. DAL). Jones should be throwing quite a bit opposite Dak Prescott and can put up the same type of game he had against the Buccaneers a couple weeks ago. He’s feeling it enough with his tight ends and short-area receivers to get a couple scores.
Fantasy Football Week 6 Sit ‘Em: Quarterbacks
Sam Darnold, Panthers (vs. MIN). It’s getting harder to trust Darnold against decent defenses, and this looks like a big Christian McCaffrey (hamstring) game if he’s healthy.
Kirk Cousins, Vikings (vs. CAR). It’s getting harder to trust Cousins against decent defense and this looks like a big Dalvin Cook (hopefully he’s healthy) game.
Derek Carr, Raiders (vs. DEN). Carr is taking some major dents, and on the road in Mile High doesn’t sound appealing at all.
Ryan Tannehill, Titans (vs. BUF). The Bills’ defense is lit, and it can douse him in a hurry should the game script get out of hand.
Ben Roethlisberger, Steelers (vs. SEA). The Seahawks’ defense can be burned, but there will be little burden on Pittsburgh’s offense in a game built for Najee Harris with no Russell Wilson (finger).
Daniel Jones, Giants (vs. LAR). He might not be cleared from his concussion to play anyway, but facing this defense with a limited receiving corps isn’t a pleasing proposition.
Tua Tagovailoa, Dolphins (at JAX in London). Jacoby Brissett would have some more streaming appeal, but Tua showed nothing we want to consider should he return from his ribs injury.
Fantasy Football Week 5 Start ‘Em: Running backs
- Derrick Henry, Titans (vs. BUF)
- Christian McCaffrey, Panthers (if he returns, vs. MIN)
- Ezekiel Elliott, Cowboys (at NE)
- James Robinson, Jaguars (vs. MIA in London)
- Jonathan Taylor, Colts (vs. HOU)
- Najee Harris, Steelers (vs. SEA)
- Austin Ekeler, Chargers (at BAL)
- Antonio Gibson, Washington (vs. KC)
- Joe Mixon, Bengals (at DET)
- Aaron Jones, Packers (at CHI)
- Nick Chubb, Browns (vs. ARI)
- Kareem Hunt, Browns (vs. ARI)
- Dalvin Cook or Alexander Mattison, Vikings (at CAR)
- Darrell Henderson, Rams (at NYG)
- D’Andre Swift, Lions (vs. CIN)
- Damien Williams, Bears (vs. GB)
Myles Gaskin, Dolphins (at JAX in London). Gaskin got the volume he needed last week, so we feel good about him in this very favorable netural-field matchup.
Leonard Fournette, Buccaneers (at PHI). He’s the main man in the backfield even with the Bucs using Ronald Jones and Giovani Bernard at times, and they can pound away well on the Eagles.
Melvin Gordon, Broncos (at LV). He should be productive in a committee in the way the Bears duo did last week.
Zack Moss, Bills (at TEN). The Bills should be able to control the action late on the ground, and he’s got some good juice as an RB2. Devin Singletary can be flexed if needed.
Miles Sanders, Eagles (vs. TB). The Eagles need to get him involved as a receiver when they’re not running him much, and this is a perfect chance to do it.
Darrel Williams, Chiefs (at WAS). He’s the plug-and-play of choice for Clyde Edwards-Helaire (knee), and look for the Chiefs to stay grounded.
Latavius Murray, Ravens (vs. LAC). The Chargers are most vulnerable against the run, so he can help the Ravens get back to 100-plus yards with a TD to boot.
Chase Edmonds, Cardinals (at CLE). He can get lost with the Cardinals feeding more mouths, but he should be healthier this week to put up something like 60 scrimmage yards and a TD.
J.D. McKissic, Washington (vs. KC). He will be involved again given Washington’s wide receiver injuries, as his production to tied to unavailability of Curtis Samuel (groin). The matchup also is exceptional for receiving backs.
Javonte Williams, Broncos (vs. LV, $5,000 on DraftKings, $5,600 on FanDuel). When will the rookie break free and break out from the Melvin Gordon commiytee? Given a Williams from Chicago did well on the Raiders, this is a chance to get Javonte rolling to provide more upside for the offense.
Sony Michel, Rams (at NYG, $4,300 on DraftKings, $5,400 on FanDuel). It’s starting to become more of a timeshare with Darrell Henderson, and the game script should allow for plenty of Sony pounding on the Giants in the second half.
Fantasy Football Week 6 Sit ‘Em: Running backs
Damien Harris, Patriots (vs. DAL). He’s an oft-injured, TD-dependent RB2 facing a tough matchup against the Cowboys’ defense.
Josh Jacobs, Raiders (at DEN). Not to pick on ‘Bama backs, but it’s difficult to feel good about playing him against the Broncos.
Devontae Booker, Giants (vs. LAR). He’s getting the main work for Saquon Barkley (ankle), so you might need to play him, but don’t expect much on the ground against this D.
Alex Collins, Seahawks (at PIT). He underwhelmed in Week 5, so if he’s starting for Chris Carson (neck) again, you should avoid him in a brutal road spot.
Jamaal Williams, Lions (vs. CIN). His usage behind D’Andre Swift can’t be trusted in any game any more.
Tony Pollard, Cowboys (at NE). They will make it more of a Zeke effort to put away the Patriots.
James Conner, Cardinals (at CLE). He needs a TD, and he won’t get it with Kyler Murray slinging the ball around.
AJ Dillon, Packers (at CHI). He’s looking good with Aaron Jones, but it’s hard to know how much he can effectively touch it.
Fantasy Football Week 6 Start ‘Em: Wide receivers
- Tyreek Hill, Chiefs (at WAS)
- Davante Adams, Packers (vs. CHI)
- Stefon Diggs, Bills (at TEN)
- Justin Jefferson, Vikings (at CAR)
- DeAndre Hopkins, Cardinals (at CLE)
- Terry McLaurin, Washington (vs. KC)
- Ja’Marr Chase, Bengals (at DET)
- Cooper Kupp, Rams (vs. NYG)
- Mike Williams, Chargers (vs. BAL)
- D.J. Moore, Panthers (vs. MIN)
- DK Metcalf, Seahawks (at PIT)
- Tyler Lockett, Seahawks (at PIT)
- Mike Evans, Buccaneers (at PHI)
- Chris Godwin, Buccaneers (at PHI)
- CeeDee Lamb, Cowboys (at NE)
- Adam Thielen, Vikings (at CAR)
- Amari Cooper, Cowboys (vs. DAL)
- Keenan Allen, Chargers (at BAL)
- Marquise Brown, Ravens (vs. LAC)
- Robert Woods, Rams (at NYG)
DeVonta Smith, Eagles (vs. TB). He should have a big breakout game against this weak secondary with a lot of targets.
Courtland Sutton, Broncos (vs. LV). Sutton looked good with Teddy Bridgewater last week, and the Raiders can’t really contain him.
Diontae Johnson and Chase Claypool, Steelers (vs. SEA). They are the men now in the passing game with no JuJu (shoulder), so expect the target shares to be dominated when not throwing to Najee Harris.
Brandin Cooks, Texans (at IND). He goes back to doing some garbage damage against a quickly depleting secondary.
Tee Higgins, Bengals (at DET). He should finally get some good trickle-down production away from Ja’Marr Chase.
Allen Robinson II, Bears (vs. GB). He’s been awful so far because of the QB, but no Jaire Alexander (shoulder) will get him on track with negative game script.
Jakobi Meyers, Patriots (vs. DAL). He can work the slot away from Trevon Diggs and should a lot of balls come his way in the second half.
Marvin Jones Jr., Jaguars (vs. MIA in London). They will make it a point to get him the ball against two underachieving top corners.
Hunter Renfrow, Raiders (at DEN). He’s the man for Derek Carr when he’s not looking Darren Waller’s way.
Michael Pittman Jr., Colts (vs. HOU, $5,500 on DraftKings, $5,800 on FanDuel). He’s locked in with Carson Wentz, and the Texans aren’t built to stop him.
Tim Patrick, Broncos (vs. LV, $5,100 on DraftKings, $6,100 on FanDuel). He loves playing with Teddy Bridgewater and should be involved nicely again.
Rondale Moore, Cardinals (at CLE, $4,600 on DraftKings, $5,700 on FanDuel). He is needed more as a dynamic cog for Kyler Murray, and the Cardinals continue to unleash him against a secondary not ready for his speed and quickness in open field.
Fantasy Football Week 5 Sit ‘Em: Wide receivers
A.J. Brown, Titans (vs. BUF). He’s not looking right yet, and this pass defense won’t help him get there.
Antonio Brown, Buccaneers (at PHI). This will be more of a Chris Godwin game.
Emmanuel Sanders, Bills (at TEN). This will be a Stefon Diggs high-volume and production game.
Kadarius Toney, Giants (vs. LAR). The rookie looks awesome — awesome enough to be shadowed by the savvy Jalen Ramsey.
Odell Beckham Jr., Browns (vs. ARI). The Baker thing isn’t working. Let’s not force it here.
Jaylen Waddle, Dolphins (vs. JAX in London). Whoever’s the QB, the usage is bad.
Henry Ruggs III, Raiders (at DEN). Here’s another non-Smith ‘Bama receiver being burned by bad connections.
Darnell Mooney, Bears (vs. GB). It should happen with Justin Fields at some point on the regular but not yet.
Laviska Shenault Jr., Jaguars (vs. MIA in London). It’s back to being a big Sha-no.
Fantasy Football Week 6 Start ‘Em: Tight ends
- Travis Kelce, Chiefs (at WAS)
- Darren Waller, Raiders (vs. DEN)
- Mark Andrews, Ravens (vs. LAC)
- Dawson Knox, Bills (at TEN)
- Noah Fant, Broncos (vs. LV)
- T.J. Hockenson, Lions (vs. CIN)
Mike Gesicki, Dolphins (at JAX in London). He makes it another solid game regardless of QB because the Jaguars won’t be able to cover him.
Tyler Higbee, Rams (at NYG). Higbee can find the end zone again, as the Giants have been gutted at linebacker and safety.
Hunter Henry, Patriots (vs. DAL). He’s being used properly in the offense now based on his talent, and he comes through again with Mac Jones.
Zach Ertz, Eagles (vs. TB). With Dallas Goedert on the COVID list, Tampa’s secondary injuries, and no Lavonte David (ankle), Ertz should be a lot more involved.
Jared Cook, Chargers (at BAL). He can sometimes not be involved in the game plan, but the Ravens are the worst team against the tight end.
Evan Engram, Giants (vs. LAR). He’s getting involved out of necessity, and it’s easier to throw on the Rams’ non-cornerbacks.
Ricky Seals-Jones, Washington ($3,000 on DraftKings, $5,000 on FanDuel). A Heinicke/RSJ stack? Sure. If you want to load up elsewhere in cash, this would be the way to go given he’s gotten good targets with Logan Thomas (hamstring) on the shelf.
Fantasy Football Week 6 Sit ‘Em: Tight ends
Dalton Schultz, Cowboys (vs. NE). He looks like a strong play in theory, but the Patriots cover the position well.
Robert Tonyan, Packers (at CHI). The Bears’ cover linebackers and safeties will keep him cold.
Tyler Conklin, Vikings (at CAR). He’s not reliable based on their fickle nature with a third non-wideout target.
Dan Arnold, Jaguars (vs. MIA in London). His floor is OK, but you’re asking for a meh game.
All Browns (vs. ARI) and all Colts (vs. HOU). The committees are maddening, so start one half of either equation at your own high risk or (maybe) decent reward.
Fantasy Football Week 6 Start ‘Em: Defenses
- Bills (at TEN)
- Steelers (vs. SEA)
- Cowboys (at NE)
- Rams (at NYG)
- Colts (vs. HOU)
Broncos (vs. LV). The Raiders are starting to fall apart in what could be an ugly game from both sides.
Packers (at CHI). Justin Fields is struggling with protecting the ball, and negative game script won’t help.
Cardinals (at CLE). The Browns’ offensive line is beat up, and Baker Mayfield can always make a few mistakes.
Dolphins (at JAX in London). Brian Flores needs more out of them, and it may actually happen against the Jaguars.
Bengals (at DET). They can get a few sacks of Jared Goff and maybe a takeaway or two to justify a stream.
Panthers (vs. MIN). Both defenses have a shot at big turnovers this week.
Vikings (at CAR, $2,900 on DraftKings, $3,700 on FanDuel). Sam Darnold is becoming a turnover machine, and Carolina’s offensive line is bound to give up some sacks to Danielle Hunter & Co.
Fantasy Football Week 6 Sit ‘Em: Defenses
Browns (vs. ARI). They are down a few folks who make enough plays.
Raiders (at DEN). They might not make enough plays, either.
Patriots (vs. DAL). Not against Dak.
Chargers (at BAL). Not against Lamar.
Ravens (vs. LAC). Not against Justin.
Bears (vs. GB). Not against Aaron.
Get more of Vinnie Iyer’s in-depth fantasy football advice for Week 6 by subscribing to the Locked On Fantasy Football podcast.